The main aim of the study is to enhance the dissolution rate of efavirenz by solid dispersion (SD) method. Efavirenz is a BCS Class II drug having low solubility and high permeability. The technique employed was solvent evaporation method. Polyvinyl pyrrolidine (PVP - K30), urea, β-cyclodextrin (β-CD) were used as hydrophilic carriers (in the ratio of 1:1, 1:3, 1:5) and methanol used as common solvent. The in-vitro dissolution study of pure drug and solid dispersions (SDs) were performed by using USP Type 1 apparatus at temperature of 37±0.5°C, 75 RPM and 900 ml of distilled water with 2% sodium lauryl sulphate (SLS) as dissolution average. The pure drug showed very slow dissolution rate and the SD’s considerably enhanced the dissolution rate. The highest improvement in dissolution rate of efavirenz was observed in formulation F6 (drug: urea, 1:5). In-vitro drug release clearly showed significant increase in the dissolution rate of efavirenz. Physicochemical characterization of solid dispersions is done by fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and X-ray diffraction (XRD) suggests a reduction in drug crystallinity results in dissolution enhancement.
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